By Philippe Derreumaux
Alzheimer's affliction is the most typical kind of senile dementia, affecting greater than 24 million humans all over the world. it's characterized pathologically via abnormally excessive degrees of neurofibrillary tangles caused by the buildup of tau protein in lifeless and loss of life neurons, and by means of increased numbers of senile plaques within the cortex and hippocampus of the mind. the foremost element of senile plaques is a small protein of 39–43 amino acids known as amyloid-β (Aβ). to date, no therapy has been proven to sluggish the development of sporadic and familial Alzheimer's disease.
A huge physique of facts issues, even though, to the early Aβ-formed oligomers because the fundamental poisonous species in Alzheimer's disorder. a robust process for constructing pharmaceutical remedies opposed to Alzheimer's is to clarify the pathways of oligomer formation and verify the constructions of the poisonous aggregates.
This ebook offers a wide ranging view throughout fresh in vitro and in vivo reports besides state of the art computing device simulations, designed to extend the readers' knowing of Aβ oligomerisation and fibril formation. while, the publication delves into the pathogenesis of familial and sporadic Alzheimer's affliction on the atomic point of detail.
Written by way of best authors of their respective fields, this publication may be worthwhile to all scientists engaged on Alzheimer's disease.
Readership: common public, PhD scholars, postdocs, in addition to all scientists operating within the following fields: Alzheimer's ailment, amyloids, neuroscience, oligomers, protofibrils, fibrils, toxicity, buildings, dynamics, kinetics, thermodynamics, all-atom and coarse grained simulations, biophysics, reminiscence, studying, transgenic mouse types, steel ions, membrane, nanoparticles, computational chemistry, drug layout and bioinformatics.
Read or Download Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry) PDF
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Extra info for Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry)
Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry) by Philippe Derreumaux